Zuprevo belongs to a class of antibiotics called macrolides. Macrolides are characterized by a 15- or 16-membered central lactone ring, and they can be classified as mono-basic, di-basic or tri-basic. They control bacteria by inhibiting protein synthesis at the ribosomal level.
Zuprevo is unique in this class because it is the world's first tri-basic 16-membered ring macrolide. Zuprevo is proven effective at controlling bacteria because it binds to more sites in the bacterial ribosome to inhibit protein synthesis.
Because of its unique structure (tri-basic, 16-membered ring) Zuprevo offers a combination of performance properties that other antibiotics can't match: prolonged concentration in lung tissue and bronchial fluids, and rapid absorption in the system.
1Menge, M. et al., Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, non-anesthetized cattle). J Vet Pharm Therap. Doj: 10.1111/J. 1365-2885, 2011. 1349.x.
*The correlation between pharmacokinetic data and clinical effectiveness is unknown.