Introducing Zuprevo™ Antibiotic
Concentrates in the Lungs for 28 Days1
Zuprevo (tildipirosin) antibiotic — an effective new macrolide — concentrates in the lungs for 28 days1 and in bronchial fluid for 21 days1 to control and treat BRD.
Why it Works
The Benefits of Using Zuprevo
Duration
Duration
Lasts 28 days in the lungs for optimal efficacy
Dosage
Dosage
One low-volume dose of 1 mL/100 lbs means less handling and more doses per bottle
Rapid Absorption
Rapid Absorption
Rapidly absorbed after administration, reaching peak plasma levels in just 45 minutes
Meat Withdrawal Time
Meat Withdrawal Time
With 21 days meat withdrawal time there’s greater flexibility to make go-to-market decisions
Unique Tri-Basic 16-Ring Macrolide
Zuprevo belongs to a class of antibiotics called macrolides. Macrolides are characterized by a 15- or 16-membered central lactone ring, and they can be classified as mono-basic, di-basic or tri-basic. They control bacteria by inhibiting protein synthesis at the ribosomal level.
Zuprevo is unique in this class because it is the world's first tri-basic 16-membered ring macrolide. Zuprevo is proven effective at controlling bacteria because it binds to more sites in the bacterial ribosome to inhibit protein synthesis.
Because of its unique structure (tri-basic, 16-membered ring) Zuprevo offers a combination of performance properties that other antibiotics can't match: prolonged concentration in lung tissue and bronchial fluids, and rapid absorption in the system.
Macrolides1Menge, M. et al., Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, non-anesthetized cattle). J Vet Pharm Therap. Doj: 10.1111/J. 1365-2885, 2011. 1349.x.
*The correlation between pharmacokinetic data and clinical effectiveness is unknown.