Zuprevo

Introducing Zuprevo Antibiotic

Concentrates in the Lungs for 28 Days1

Zuprevo (tildipirosin) antibiotic — an effective new macrolide — concentrates in the lungs for 28 days1 and in bronchial fluid for 21 days1 for the treatment of bovine respiratory disease (BRD).

Why it Works

The Benefits of Using Zuprevo

Duration

Duration

Lasts 28 days in the lungs for optimal efficacy

Dosage

Dosage

One low-volume dose of 1 mL/100 lbs means less handling and more doses per bottle

Rapid Absorption

Rapid Absorption

Rapidly absorbed after administration, reaching peak plasma levels in just 45 minutes

Meat Withdrawal Time

Meat Withdrawal Time

With 21 days meat withdrawal time there’s greater flexibility to make go-to-market decisions

Unique Tri-Basic 16-Ring Macrolide

Zuprevo belongs to a class of antibiotics called macrolides. Macrolides are characterized by a 15- or 16-membered central lactone ring, and they can be classified as mono-basic, di-basic or tri-basic. They control bacteria by inhibiting protein synthesis at the ribosomal level.

Zuprevo is unique in this class because it is the world's first tri-basic 16-membered ring macrolide. Zuprevo is proven effective at controlling bacteria because it binds to more sites in the bacterial ribosome to inhibit protein synthesis.

Because of its unique structure (tri-basic, 16-membered ring) Zuprevo offers a combination of performance properties that other antibiotics can't match: prolonged concentration in lung tissue and bronchial fluids, and rapid absorption in the system.

Macrolides

1Menge, M. et al., Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, non-anesthetized cattle). J Vet Pharm Therap. Doj: 10.1111/J. 1365-2885, 2011. 1349.x. The correlation between pharmacokinetic data and clinical relevance is unknown.

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